We Are Building Targeted Radiotherapy 2.0
dGenThera is a next-generation targeted radiotherapeutics company advancing a differentiated pipeline of theranostic agents optimized for safety, scalability, and precision oncology. dGenThera’s proprietary chemistry enables exquisitely matched theranostic pairs—leveraging Astatine-211 (211At), Iodine-131 (131I), and Fluorine-18 (18F)—with engineered stable carbon-halogen bonds to drive accurate dosimetry, improve patient stratification, and reduce off-target toxicity.
Our Technology: Exquisitely Matched Theranostic Triplets
- Carbon-I and carbon-At bonds are stabilized against dehalogenation
- Exquisitely matched → faithful reporting → highest resolution (18F) PET in biodistribution studies
- Single particle emitters result in completely predictable dosimetry
- Biodistribution of therapeutic emitters → directly confirmable with SPECT
- Short half-life of 211At reduces healthy tissue exposure; single particle emission (no wandering daughters) reduces delayed toxicity
dGenThera’s Molecules
Small Molecules
Transporter substrates (accumulate in tumor cells)
Target several solid tumors
Designed to cross the blood-brain barrier
Tagging Platform for Bioligands
Small (~500 amu) and diverse tags
Many attachment chemistries
Physicochemical properties can be matched to tumor-targeting fusion partner
Small molecule 211At-DGT-77 demonstrates compelling efficacy in vivo
- Breast cancer xenograft tumorized mice received a single 2 MBq dose of 211At-DGT-77 per mouse (>98% radiochemical purity)
- 211At-DGT-77 shows ~100% tumor growth inhibition (TGI) at four weeks post-dosing
dGT’s lead bioligand-tagged asset demonstrates remarkable biodistribution
- Images show biodistribution of 131I-DGT-207 in an undisclosed human cancer xenograft model at 4 and 24 h post-injection.
- 131I-DGT-207 demonstrates biodistribution that is superior to both the chelated metal TRTs and to other I-131 TRTs that have been designed for this target. This shows the utility of matching/balancing of tag and ligand physicochemical properties, and the effectiveness of our tags’ protection from in vivo dehalogenation.
